RAF KINASE INHIBITOR V

Name	N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide
Synonyms	PLX4720 CS-1917 PLX-4720 PLX 4720 RAF KINASE INHIBITOR V N-[3-[(5-Chloro-1H-pyrrol... N-[3-(5-chloro-1H-pyrrolo[2,3-b]pyridine-3-carbonyl)-2,4-difluoro-phenyl]propane-1-sulfonamide N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide 1-PropanesulfonaMide, N-[3-[(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]- N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide PLX 4720 PLX 4720 N-[3-[(5-Chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)carbonyl]-2,4-difluorophenyl]-1-propanesulfonamide
CAS	918505-84-7
InChI	InChI=1/C17H14ClF2N3O3S/c1-2-5-27(25,26)23-13-4-3-12(19)14(15(13)20)16(24)11-8-22-17-10(11)6-9(18)7-21-17/h3-4,6-8,23H,2,5H2,1H3,(H,21,22)

Molecular Formula	C17H14ClF2N3O3S
Molar Mass	413.83
Density	1.55
Melting Point	230-233oC
Solubility	DMSO (Slightly), Methanol (Slightly, Heated)
Appearance	Orange-yellow solid
Color	White to Off-White
pKa	6.20±0.10(Predicted)
Storage Condition	+2C to +8C
Refractive Index	1.645
In vitro study	PLX-4720 high affinity and activity B- Raf10 μm PLX-4720 treatment of PTEN
In vivo study	PLX-4720 8505c tumors treated with 20 mg/kg daily oral administration of dependent B- Raf PLX-4720 at 30 mg/kg daily significantly inhibited tumor growth by more than 90%, distant lung metastases were also significantly reduced.

Last Update：2024-01-02 23:10:35

biological activity	PLX-4720 is a potent, selective B- RafV600E inhibitor with an IC50 of 13 nM, acting on c-Raf-1(Y340D and Y341D mutants) was moderately effective, acting on B- RafV600E being 10-fold more selective than acting on wild-type B- Raf. PLX-4720 is a potent, selective B- RafV600E inhibitor with an IC50 of 13 nM in a cell-free assay, equally effective at c-Raf-1(Y340D and Y341D mutants), the selectivity was 10-fold higher for B- RafV600E than for wild-type B- Raf.
Target	Value
C-Raf-1 (Y340D/Y341D) (Cell-free assay)	6.7 nM
B-Raf (V600E) (Cell-free assay)	13 nM
BRK (Cell-free assay)	130 nM
B-Raf (Cell-free assay)	160 nM

Last Update：2024-04-09 20:02:46

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CAS: 918505-84-7
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Product Name: PLX-4720 Visit Supplier Webpage Request for quotation
CAS: 918505-84-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409

Wechat: 18301782025

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RAF KINASE INHIBITOR V
26530-20-1

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